Placental Transfer of Rilpivirine in anEx VivoHuman Cotyledon Perfusion Model
نویسندگان
چکیده
منابع مشابه
Placental transfer of rilpivirine in an ex vivo human cotyledon perfusion model.
Placental transfers of the HIV nonnucleoside reverse transcriptase inhibitor rilpivirine were investigated in 8 term human cotyledons perfused with rilpivirine (400 ng/ml) in the maternal-to-fetal direction. The mean fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 15 to 90 min) was 26% ± 8% (mean ± standard deviation), and the clearance index (rilpivirine FTR/antipy...
متن کاملErratum for Mandelbrot et al., placental transfer of rilpivirine in an ex vivo human cotyledon perfusion model.
Laurent Mandelbrot, Dominique Duro, Emilie Belissa, Gilles Peytavin Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstétrique, Hôpitaux Universitaires Paris-Nord Val de Seine, Colombes, France; Université Paris-Diderot, Université Sorbonne Paris-Cité, DHU Risks in Pregnancy, Paris, France; INSERM U1018, Kremlin-Bicêtre, France; Assistance Publique-Hôpitaux...
متن کاملPlacental transfer of darunavir in an ex vivo human cotyledon perfusion model.
Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±2.1%, and the mean (±SD) clearance index (darunavir FTR/antipyrine FTR) was 40...
متن کاملPlacental transfer of maraviroc in an ex vivo human cotyledon perfusion model and influence of ABC transporter expression.
Nowadays, antiretroviral therapy is recommended during pregnancy to prevent mother-to-child transmission of HIV. However, for many antiretroviral drugs, including maraviroc, a CCR5 antagonist, very little data exist regarding placental transfer. Besides, various factors may modulate this transfer, including efflux transporters belonging to the ATP-binding cassette (ABC) transporter superfamily....
متن کاملValproic acid transfer across human placental cotyledon during dual perfusion in vitro.
Valproic acid (VPA ) is a well-known antiepileptic drug with a significant teratogenic effect when administered during pregnancy. To investigate the transplacental transport of VPA, we used an in vitro experiment of dual perfusion of a human placental cotyledon. Eighteen normal placentas at term were investigated; ten were treated with a therapeutic dose of VPA (initial level at maternal circul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2015
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00075-15